sábado, 29 de febrero de 2020

Antipsychotic Drugs, Fracture Risk, and Frailty in Older Patients

Antipsychotic Drugs, Fracture Risk, and Frailty in Older Patients: I read the recent article published in this journal and written by Gafoor et al1 with
great interest. The authors conducted a prospective study to evaluate the effect of
first- or second-generation antipsychotic drugs on fracture risk with special reference
to levels of frailty in patients aged 80 years and older. Fracture incidence increased
with frailty progression, and frail patients received more frequent antipsychotic
drug treatment than nonfrail patients. Adjusted rate ratios (RRs) [95% confidence
intervals (CIs)] of the first and second generation antipsychotic drug exposure on
the risk of any fracture were 1.24 (1.07‒1.43) and 1.12 (1.01‒1.24), respectively.

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