sábado, 29 de febrero de 2020

Response to Letter: Antipsychotic Drugs, Fracture Risk, and Frailty in Older Patients - Journal of the American Medical Directors Association

Response to Letter: Antipsychotic Drugs, Fracture Risk, and Frailty in Older Patients - Journal of the American Medical Directors Association: We are grateful for the opportunity to respond to comments raised by Tomoyuki Kawada.
The studies1,2 referred to by Dr Kawada show a positive association between increasing
frailty level and risk of fracture. Kawada highlights differences in the reported
magnitude of the estimates of association in these studies (inter alia). These differences
could be explained by (1) differences in the populations at risk, which are not identical
in the 2 studies with systematic differences in sample selection; (2) analyses are
not identical and adjustment for confounding variables differs between these studies;
or (3) odds ratios are expected to provide more extreme estimates than relative risks.

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